Kuros Biosciences to present at upcoming U.S. spine conferences

MagnetOs bone graft is supported by a growing set of preclinical data demonstrating equiva-lence to the current gold standard, autograft, with over three years of clinical experience since its first use in the UK in May 2017.

Details of the conferences are as follows:

• 55th Annual Meeting of the Rocky Mountain Neurosurgical Society
  Jackson, WY, U.S.
  June 19 – 23, 2021
   
• 16th Annual Meeting of the Korean American Spine Society
  Carlsbad, CA, U.S.
  July 1-3, 2021
  Presenter: Dr. John H. Chi, MD, MPH
   
• Spine Summit 2021 – The 37th Annual Meeting of the AANS/CNS Section on Disor-ders of the Spine and Peripheral Nerves
  San Diego, CA, U.S.
  July 28-31, 2021
  Presenter: Dr. Alpesh. A. Patel, MD,

• Texas Association of Neurosurgeons 2021 Annual Meeting
  Bastrop, TX, U.S.
  August 5-8, 2021

• Augusta Spine Symposium
  North Augusta, SC, U.S.
  August 13, 2021
   
• Michigan Association of Neurological Surgeons 39th Annual Meeting
  Traverse City, MI, U.S.
  August 27-29, 2021

About Fibrin-PTH (KUR-113)
Fibrin-PTH (KUR-113) consists of a natural fibrin-based healing matrix with an immobilized targeted bone growth factor (truncated human parathyroid hormone (PTH) analog). Fibrin-PTH (KUR-113) is designed to be applied directly into and around an intervertebral body fusion device as a gel, where it polymerizes in situ. Fibrin-PTH (KUR-113) functions via the well-established mechanism of action of parathyroid hormone; has been demonstrated in animal models of spinal fusion to be comparable to rhBMP-2; and has been shown in preclinical studies to be easy to use and ideal for open or minimally invasive techniques. The safety & efficacy of Fibrin PTH (KUR-113) has not yet been evaluated for spinal fusion in humans.

About MagnetOs bone graft 
MagnetOs bone graft has an advanced submicron surface topography that leads to the formation of bone in spinal fusion defects rather than scar tissue. In preclinical models, MagnetOs preferentially directs the body’s early wound healing response toward the bone-forming pathway, an effect that is so potent that bone can be formed even in soft tissues without the need for added cells or growth factors. This ground-breaking research led to Kuros attaining an osteoinductive claim for MagnetOs in Europe and it is now supported by more than three years of clinical experience since its launch in the United Kingdom in May 2017. Results from in vitro or in vivo laboratory testing may not be pre-dictive of clinical experience in humans. MagnetOs is not cleared by TGA or FDA as an osteoinductive bone graft.

Indications statement
U.S.: MagnetOs is an implant intended to fill bony voids or gaps of the skeletal system, i.e., posterolateral spine. Mag-netOs must be used with autograft as a bone graft extender in the posterolateral spine. These osseous defects may be surgically created or the result of traumatic injury to the bone and are not intrinsic to the stability of the bony structure.
All markets: Please refer to the instructions for use for your local region for a full list of indications, contraindications, warnings, and precautions.

Forward Looking Statements 
This media release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. You are urged to consider statements that include the words “will” or “expect” or the negative of those words or other similar words to be uncertain and forward-looking. Factors that may cause actual results to differ materially from any future results expressed or implied by any forward-looking statements include scientific, business, economic and financial factors, Against the background of these uncertainties, readers should not rely on forward-looking statements. The Company assumes no responsibility for updating forward-looking statements or adapting them to future events or developments.