Application areas and exposure principles for in vitro lung cell research

VITROCELL^® devices are designed to evaluate the potential health risks of inhalable substances without relying on laboratory animals. These systems expose lung cells at the air-liquid interface, simulating real-world inhalation conditions.

A newly released video presentation highlights key in vitro exposure systems designed for all types of aerosols, including:

• Gases, complex mixtures, and particles in continuous flow
• Liquids and suspensions via single droplet sedimentation
• Dry powders in minimal quantities

Watch the video on our YouTube channel Exposure Systems for in vitro inhalation research

Comprehensive Cell Exposure Systems
VITROCELL^® offers a variety of advanced cell exposure systems capable of directly exposing respiratory tract cells to gases, particles, and complex mixtures.

Key steps of the exposure process:

1. Cell Cultivation: Cells are cultured on permeable membrane inserts.
2. Exposure Setup: The inserts are placed in exposure systems maintained at 37°C. The basal side of the cells receives nutrients through the membrane, while the apical side remains exposed to airborne substances at the air-liquid interface, closely mimicking human respiratory conditions.
3. Exposure Process: Airborne compounds interact directly with the cells without interference from a liquid barrier.
4. Post-Exposure Analysis: The membrane inserts are removed, and the cells undergo standard endpoint analyses.

Supporting the Reduction of Animal Testing
VITROCELL^® systems are widely used in leading laboratories worldwide, helping reduce the need for animal testing in inhalation research. Their customers include:

• Research institutes
• Industrial and pharmaceutical laboratories
• Contract research organizations
• Regulatory authorities

VITROCELL^® is a trusted partner in driving innovative advancements in toxicological and inhalation research globally.